Parkin (protein)

Parkin is a protein that in humans is encoded by the PARK2 gene. Mutations in this gene result in Parkinson's disease, a neurodegenerative disorder. This protein is found in the mitochondria and its primary function is to aid in the removal of damaged mitochondria, preventing the build-up of non-functional proteins or organelles within the cell.

Function

The Parkin protein is part of a pathway that signals for the destruction of damaged mitochondria, a process known as mitophagy. This is a crucial process for maintaining the health of cells and their efficient functioning, particularly in the nervous system.

Clinical significance

Mutations in the PARK2 gene are linked to a form of Parkinson's disease known as autosomal recessive juvenile Parkinson disease. These mutations often result in a loss of function of the Parkin protein, leading to an accumulation of damaged mitochondria in neurons. This can cause the death of these cells, leading to the symptoms of Parkinson's disease.

See also

• PARK2
• Parkinson's disease
• Mitophagy

References

Parkin (protein) Resources
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