Pelubiprofen

Comprehensive article on Pelubiprofen, a nonsteroidal anti-inflammatory drug

Pelubiprofen is a nonsteroidal anti-inflammatory drug (NSAID) used primarily for its analgesic and anti-inflammatory properties. It is commonly prescribed for the treatment of rheumatoid arthritis, osteoarthritis, and other musculoskeletal disorders. Pelubiprofen is known for its efficacy in reducing pain and inflammation with a relatively favorable safety profile compared to other NSAIDs.

Pharmacology

Pelubiprofen works by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are involved in the synthesis of prostaglandins. Prostaglandins are lipid compounds that play a key role in the inflammatory process, pain sensation, and fever. By reducing the production of prostaglandins, pelubiprofen alleviates symptoms associated with inflammation and pain.

Pharmacokinetics

Pelubiprofen is well absorbed from the gastrointestinal tract when administered orally. It has a high bioavailability and is extensively bound to plasma proteins, primarily albumin. The drug undergoes hepatic metabolism, primarily through hydroxylation and conjugation, and is excreted mainly via the kidneys. The elimination half-life of pelubiprofen is approximately 4 to 6 hours, allowing for dosing multiple times a day.

Clinical Uses

Pelubiprofen is indicated for the management of:

• Rheumatoid arthritis
• Osteoarthritis
• Acute musculoskeletal pain
• Postoperative pain

Adverse Effects

Common adverse effects of pelubiprofen include gastrointestinal disturbances such as nausea, dyspepsia, and abdominal pain. Like other NSAIDs, it may increase the risk of gastrointestinal bleeding, peptic ulcer disease, and renal impairment. Patients with a history of cardiovascular disease should use pelubiprofen with caution due to potential cardiovascular risks associated with NSAID use.

Contraindications

Pelubiprofen is contraindicated in patients with:

• Known hypersensitivity to pelubiprofen or other NSAIDs
• Active peptic ulcer disease
• Severe hepatic or renal impairment
• History of asthma attacks or allergic reactions after taking aspirin or other NSAIDs

Interactions

Pelubiprofen may interact with other medications, including:

• Anticoagulants such as warfarin, increasing the risk of bleeding
• Antihypertensive drugs, potentially reducing their efficacy
• Other NSAIDs or corticosteroids, increasing the risk of gastrointestinal side effects

Also see

• Nonsteroidal anti-inflammatory drug
• Cyclooxygenase
• Prostaglandin
• Rheumatoid arthritis
• Osteoarthritis