Peptidase inhibitor 15

Peptidase inhibitor 15 (PI15) is a protein that in humans is encoded by the PI15 gene. It is a member of the peptidase inhibitor family, which is a group of proteins that regulate the activity of peptidase enzymes.

Function

The PI15 gene encodes a protein that is a member of the peptidase inhibitor family. This protein is a potent inhibitor of trypsin and plasmin, two types of peptidase enzymes that break down proteins. By inhibiting these enzymes, PI15 plays a crucial role in regulating protein degradation in the body.

Structure

The PI15 protein is composed of 147 amino acids and has a molecular weight of approximately 16 kDa. It contains a single peptidase inhibitor domain, which is responsible for its inhibitory activity.

Clinical significance

Alterations in the PI15 gene have been associated with various diseases. For example, mutations in this gene have been linked to cancer, as they can lead to uncontrolled protein degradation and cell growth. Additionally, PI15 has been implicated in inflammation and immune response, as it can regulate the activity of enzymes involved in these processes.

See also

• Peptidase
• Protein degradation
• Trypsin
• Plasmin