Perimycin

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An overview of the antibiotic Perimycin


Overview[edit | edit source]

Chemical structure of Perimycin A

Perimycin is a macrolide antibiotic known for its effectiveness against a variety of bacterial infections. It is derived from the bacterium Streptomyces and is primarily used in the treatment of infections caused by Gram-positive bacteria.

Mechanism of Action[edit | edit source]

Perimycin functions by inhibiting bacterial protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thereby preventing the translocation of peptidyl tRNA from the A-site to the P-site. This action effectively halts the growth of the bacteria, allowing the immune system to eliminate the infection.

Clinical Uses[edit | edit source]

Perimycin is used in the treatment of various infections, including:

Side Effects[edit | edit source]

Common side effects of Perimycin include:

Pharmacokinetics[edit | edit source]

Perimycin is administered orally and is well absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted primarily in the bile.

Resistance[edit | edit source]

Bacterial resistance to Perimycin can occur through various mechanisms, including:

  • Modification of the ribosomal binding site
  • Efflux pumps that expel the antibiotic from the bacterial cell
  • Enzymatic degradation of the antibiotic

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