Perisinusoidal space

Perisinusoidal space (also known as Space of Disse) is a small area in the liver between a hepatocyte and a sinusoid. This space plays a crucial role in the exchange of materials between hepatocytes and blood.

Structure

The perisinusoidal space is a narrow, blood-filled space located between the endothelial cells of the sinusoid and the hepatocytes. It is approximately 17 μm wide and is filled with a loose network of collagen fibers and stellate cells.

Function

The main function of the perisinusoidal space is to facilitate the exchange of various substances between the blood in the sinusoids and the hepatocytes. It allows for the passage of oxygen, nutrients, and hormones from the blood to the hepatocytes, and the removal of waste products from the hepatocytes to the blood.

Clinical significance

Abnormalities in the perisinusoidal space can lead to various liver diseases. For example, fibrosis of the perisinusoidal space can lead to cirrhosis, a serious liver disease characterized by the replacement of normal liver tissue with scar tissue.

See also

• Hepatocyte
• Sinusoid (blood vessel)
• Liver disease

References

Perisinusoidal space Resources
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