Perisinusoidal space

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Perisinusoidal space

The perisinusoidal space, also known as the space of Disse, is a small area in the liver located between a hepatocyte and a sinusoid. This space plays a crucial role in the liver's function, particularly in the exchange of substances between the blood and liver cells.

Structure

The perisinusoidal space is found in the liver lobules, which are the functional units of the liver. It is situated between the endothelial cells lining the sinusoids and the hepatocytes. The space of Disse contains hepatic stellate cells (also known as Ito cells), which store vitamin A and produce extracellular matrix components. Additionally, this space contains microvilli from hepatocytes, which increase the surface area for exchange.

Function

The primary function of the perisinusoidal space is to facilitate the transfer of nutrients, oxygen, and waste products between the blood and hepatocytes. The endothelial cells lining the sinusoids are fenestrated, allowing plasma to flow into the space of Disse. This plasma bathes the microvilli of hepatocytes, enabling efficient exchange of substances.

Clinical Significance

Changes in the perisinusoidal space can be indicative of various liver diseases. For instance, in liver fibrosis, the space of Disse becomes filled with excess extracellular matrix, which can impede the exchange of substances and lead to liver dysfunction. Cirrhosis is another condition where the architecture of the perisinusoidal space is significantly altered.

See also

• Liver sinusoid
• Hepatocyte
• Liver fibrosis
• Cirrhosis
• Hepatic stellate cell