Pethidinic acid

Pethidinic Acid is a synthetic opioid analgesic related to pethidine (meperidine) which is used in medicine for the treatment of severe pain. It is a potent analgesic, approximately three times more potent than morphine in analgesic effect.

Chemistry

Pethidinic acid is a member of the class of compounds known as phenylpiperidines. It is a phenylpiperidine and a tertiary carboxylic acid amide. It is a conjugate acid of a pethidinic acid anion.

Pharmacology

Pethidinic acid acts on the central nervous system and alters the perception of pain in the brain. It binds to the mu-opioid receptors and induces a series of biochemical responses leading to pain relief. The drug also has sedative effects and can cause respiratory depression in high doses.

Side Effects

Like other opioids, pethidinic acid can cause a range of side effects. These can include nausea, vomiting, constipation, dry mouth, drowsiness, and confusion. More serious side effects can include respiratory depression, low blood pressure, and addiction.

Interactions

Pethidinic acid can interact with a number of other medications, including other opioids, sedatives, and certain antidepressants. It is important to inform your healthcare provider of all medications you are currently taking to avoid potential interactions.

See Also

• Opioid
• Pethidine
• Phenylpiperidines
• Mu-opioid receptor

References

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