Phagosome

From WikiMD.com - Food, Medicine & Wellness Encyclopedia

(Redirected from Phagosomes)

Phagosome

A phagosome is a vesicle formed around a particle engulfed by a phagocyte during phagocytosis. Professional phagocytes include macrophages, neutrophils, and dendritic cells (DCs). A phagosome is a cellular compartment in which pathogenic microorganisms can be killed and digested. Phagosomes fuse with lysosomes in their maturation process, forming phagolysosomes.

Formation[edit | edit source]

The formation of the phagosome is the initial step in the process of phagocytosis, and involves the rearrangement of the cytoskeleton and the plasma membrane of the phagocyte. The process is triggered by the binding of microorganisms or particles to cell surface receptors on the phagocyte. This binding triggers a response in the phagocyte, leading to the engulfment of the particle or microorganism.

Maturation[edit | edit source]

The maturation of the phagosome involves a series of fusion events with endosomes and lysosomes, which provide the phagosome with the necessary components for the degradation of its contents. The maturation process is also regulated by a variety of cellular mechanisms, including the action of Rab GTPases.

Function[edit | edit source]

The main function of the phagosome is to degrade its contents, a process that is essential for the defense against infection. The degradation is carried out by enzymes and other molecules that are delivered to the phagosome during its maturation process. The products of this degradation can then be presented on the surface of the phagocyte as antigens, triggering an immune response.

See also[edit | edit source]

WHO Rod.svg
This article is a medical stub. You can help WikiMD by expanding it!
PubMed
Wikipedia
WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Transform your life with W8MD's budget GLP1 injections from $125

W8mdlogo.png
W8MD weight loss doctors team

W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.

Why choose W8MD?

Book Your Appointment

Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD