Pharmacodynamics of estradiol
Pharmacodynamics of Estradiol
Estradiol is a naturally occurring steroid hormone and the primary female sex hormone. It is involved in the regulation of the menstrual cycle and estrus cycle. The pharmacodynamics of estradiol refer to the biochemical and physiological effects of estradiol on the body and its mechanisms of action.
Mechanism of Action[edit | edit source]
Estradiol exerts its effects by binding to and activating the estrogen receptor (ER), a class of intracellular receptor that is expressed in various tissues including the uterus, breast, vagina, and brain. Upon binding, the estradiol-ER complex translocates to the cell nucleus, where it acts as a transcription factor to modulate the expression of estrogen-responsive genes.
Effects on the Body[edit | edit source]
Estradiol has widespread effects on the body. It is crucial for the development and maintenance of female secondary sexual characteristics, such as the growth of the breasts and the widening of the hips. It also plays a key role in the regulation of the menstrual cycle and is involved in the maintenance of bone health.
In the brain, estradiol influences mood, cognition, and pain perception. It has neuroprotective effects and can influence the risk of neurodegenerative diseases such as Alzheimer's disease.
Pharmacokinetics[edit | edit source]
The pharmacokinetics of estradiol, including its absorption, distribution, metabolism, and excretion, also influence its pharmacodynamics. Estradiol can be administered orally, transdermally, or intramuscularly. It is metabolized primarily in the liver and excreted in the urine and feces.
Side Effects and Risks[edit | edit source]
Like all medications, estradiol can have side effects. These can include nausea, breast tenderness, and an increased risk of blood clots. Long-term use of estradiol can increase the risk of certain cancers, including breast cancer and endometrial cancer.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
 | This endocrinology article is a stub. You can help WikiMD by expanding it. |
This gynecology related article is a stub. You can help WikiMD by expanding it.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
