Phenadoxone

Phenadoxone is a narcotic analgesic that is rarely used in medicine. It is synthesized from thebaine. It is used for the relief of moderate to severe pain, such as that experienced after surgery or from chronic conditions such as cancer. It is also used for the treatment of opioid dependence.

Pharmacology

Phenadoxone is a semi-synthetic opioid that acts as a mu-opioid receptor agonist. It is structurally related to methadone, a synthetic opioid used in the treatment of opioid dependence. Phenadoxone has a high affinity for the mu-opioid receptor, which is responsible for its analgesic effects. It also has a lower affinity for the kappa-opioid receptor and the delta-opioid receptor, which may contribute to its analgesic effects and side effects.

Side Effects

Like other opioids, phenadoxone can cause a range of side effects. These can include nausea, vomiting, constipation, drowsiness, dizziness, and respiratory depression. In severe cases, it can cause coma or death. It can also cause physical dependence and withdrawal symptoms if used for a long period of time.

Legal Status

Phenadoxone is a Schedule II controlled substance in the United States, meaning it has a high potential for abuse and dependence. It is also controlled under the Single Convention on Narcotic Drugs of 1961.

See Also

• Opioid
• Thebaine
• Methadone

Phenadoxone Resources
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