Phenestrol
Phenestrol[edit | edit source]
Phenestrol is a synthetic nonsteroidal estrogen of the stilbestrol group, which was developed for medical use. It is known for its estrogenic properties and has been used in various therapeutic applications.
Chemical Properties[edit | edit source]
Phenestrol belongs to the class of stilbestrol estrogens, which are characterized by their nonsteroidal structure. The chemical structure of Phenestrol is depicted in the image to the right. This structure is similar to other compounds in the stilbestrol group, which are known for their ability to mimic the biological activity of natural estrogens.
Mechanism of Action[edit | edit source]
Phenestrol, like other estrogens, exerts its effects by binding to and activating the estrogen receptors in various tissues. This activation leads to the modulation of gene expression and the regulation of numerous physiological processes, including the development and maintenance of female secondary sexual characteristics, regulation of the menstrual cycle, and effects on bone density.
Medical Uses[edit | edit source]
Phenestrol has been used in the treatment of various conditions that benefit from estrogen therapy. These include:
- Hormone replacement therapy (HRT) in postmenopausal women to alleviate symptoms such as hot flashes and osteoporosis.
- Treatment of certain types of breast cancer and prostate cancer, where estrogen therapy can be beneficial.
- Management of menstrual disorders and ovarian failure.
Side Effects[edit | edit source]
As with other estrogenic compounds, Phenestrol can cause a range of side effects. Common side effects include:
- Nausea and vomiting
- Breast tenderness
- Headache
- Increased risk of thromboembolic events
Long-term use of estrogens has been associated with an increased risk of certain types of cancer, such as endometrial cancer and breast cancer.
Pharmacokinetics[edit | edit source]
Phenestrol is administered orally and is absorbed through the gastrointestinal tract. It undergoes extensive metabolism in the liver, and its metabolites are excreted primarily in the urine. The pharmacokinetic profile of Phenestrol is similar to that of other nonsteroidal estrogens.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
