Phenestrol
Phenestrol is a synthetic, nonsteroidal estrogen that was previously used in medicine but has since been discontinued. It is related to diethylstilbestrol and ethamoxytriphetol and was primarily used in the treatment of menopausal symptoms and prostate cancer.
History[edit | edit source]
Phenestrol was first synthesized in the 1940s and was used in medicine for several decades. However, it was discontinued due to concerns about its safety and efficacy.
Medical uses[edit | edit source]
Phenestrol was primarily used in the treatment of menopausal symptoms and prostate cancer. It was also used in the treatment of breast cancer and other conditions that are responsive to estrogen therapy.
Pharmacology[edit | edit source]
As a synthetic, nonsteroidal estrogen, phenestrol binds to and activates the estrogen receptor, thereby exerting estrogenic effects in the body. It is related to diethylstilbestrol and ethamoxytriphetol, which are also synthetic, nonsteroidal estrogens.
Side effects[edit | edit source]
The side effects of phenestrol are similar to those of other estrogens and include nausea, vomiting, breast tenderness, menstrual irregularities, and fluid retention. Long-term use of phenestrol can also lead to an increased risk of endometrial cancer and other serious health problems.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD