Phosphoglucomutase

Phosphoglucomutase (PGM) is an enzyme that plays a crucial role in carbohydrate metabolism. This enzyme is involved in the glycolysis and gluconeogenesis pathways, facilitating the interconversion of glucose-1-phosphate and glucose-6-phosphate.

Function

Phosphoglucomutase catalyzes the transfer of a phosphate group from the 1-position of a glucose molecule to the 6-position, and vice versa. This reaction is essential for the breakdown of glucose for energy production (glycolysis) and the synthesis of glucose from non-carbohydrate precursors (gluconeogenesis).

Structure

Phosphoglucomutase is a monomeric enzyme composed of a single polypeptide chain. The enzyme contains a serine residue at its active site, which is phosphorylated during the catalytic cycle.

Clinical significance

Deficiency in phosphoglucomutase can lead to a rare genetic disorder known as PGM deficiency. This condition is characterized by muscle weakness, exercise intolerance, and other symptoms. Diagnosis is typically made through enzyme analysis or genetic testing.

See also

• Glycolysis
• Gluconeogenesis
• Phosphoglucomutase deficiency

References

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