Piperonyl butoxide

From WikiMD's Food, Medicine & Wellness Encyclopedia

Piperonyl butoxide (PBO) is a chemical compound often used as a synergist in the application of insecticides. It is a semi-synthetic derivative of safrole.

History[edit | edit source]

Piperonyl butoxide was first registered in the United States in 1957. It was initially used in combination with pyrethrins, a class of naturally occurring insecticides, to enhance their effectiveness.

Chemistry[edit | edit source]

Piperonyl butoxide is an organic compound that is classified as a waxy solid at room temperature. It has a slight, characteristic odor. The chemical formula for piperonyl butoxide is C19H30O5.

Mode of Action[edit | edit source]

Piperonyl butoxide works by inhibiting the natural defense mechanisms of insects. It blocks the action of enzymes that would otherwise break down the insecticides before they can take effect. This allows the insecticides to be more effective.

Uses[edit | edit source]

Piperonyl butoxide is used in a variety of insecticide products, including those for home, garden, and veterinary use. It is often combined with other insecticides such as permethrin, tetramethrin, and resmethrin.

Safety and Environmental Impact[edit | edit source]

While piperonyl butoxide is not considered highly toxic to humans or animals, it can cause irritation if it comes into contact with the skin or eyes. It is also toxic to fish and other aquatic organisms.

Regulation[edit | edit source]

In the United States, products containing piperonyl butoxide are regulated by the Environmental Protection Agency (EPA). The EPA classifies piperonyl butoxide as a Group C, possible human carcinogen.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD