Poly(adp-ribose) polymerase family member 14
Poly(ADP-ribose) polymerase family member 14 (PARP14) is a protein that in humans is encoded by the PARP14 gene. This protein is a member of the poly(ADP-ribose) polymerase (PARP) family, which is involved in a variety of cellular processes such as DNA repair, genomic stability, and programmed cell death.
Function[edit | edit source]
PARP14 is known to play a role in the regulation of gene expression and has been implicated in the immune response. It acts as a mono-ADP-ribosyltransferase, modifying target proteins by adding ADP-ribose moieties. This post-translational modification can alter the function of the target proteins, affecting various cellular pathways.
Clinical significance[edit | edit source]
Alterations in the expression or function of PARP14 have been associated with several diseases, including cancer and autoimmune disorders. Research suggests that PARP14 may have a role in the progression of certain types of cancer by influencing tumor microenvironment and immune evasion.
Interactions[edit | edit source]
PARP14 interacts with various proteins involved in signal transduction and transcriptional regulation. These interactions are crucial for its role in modulating cellular responses to external stimuli.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
Template:Poly(ADP-ribose) polymerases
| Excision repair | |
|---|---|
| Other forms of repair | |
| Other/ungrouped proteins | |
| Regulation | |
| Other/ungrouped | |
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Contributors: Prab R. Tumpati, MD
