Poly(adp-ribose) polymerase family member 14

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a protein that in humans is encoded by the PARP14 gene. It is a member of the Poly(ADP-ribose) polymerase family, a group of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.

Function

PARP14 is a catalytic protein that plays a crucial role in the immune system. It is involved in the regulation of macrophage activation and inflammation. The protein is also known to interact with histones and DNA, and may be involved in the process of DNA repair.

Structure

The PARP14 protein is composed of several domains, including three zinc finger domains, two BRCT domains, and a catalytic domain. The zinc finger domains are involved in DNA binding, while the BRCT domains are involved in protein-protein interactions. The catalytic domain is responsible for the protein's enzymatic activity.

Clinical significance

Alterations in the PARP14 gene have been associated with various diseases, including cancer, autoimmune diseases, and infectious diseases. In particular, overexpression of PARP14 has been observed in certain types of cancer, suggesting a potential role in tumor progression.

File:PARP14 protein structure.jpg

Structure of the PARP14 protein.

See also

• Poly(ADP-ribose) polymerase
• DNA repair
• Macrophage