Polyhexamethylene guanidine

Polyhexamethylene guanidine

Polyhexamethylene guanidine (PHMG) is a polymeric biocide that is often used in a variety of applications due to its broad-spectrum antimicrobial properties. It is a member of the guanidine family of chemicals, which are known for their ability to disrupt the cell membranes of microorganisms, leading to their death.

Chemical Structure

PHMG is a polymer that is made up of repeating units of hexamethylene guanidine. The hexamethylene groups provide the backbone of the polymer, while the guanidine groups are responsible for its antimicrobial activity. The guanidine groups can form multiple hydrogen bonds with the cell membranes of microorganisms, disrupting their structure and function.

Applications

PHMG is used in a wide range of applications due to its antimicrobial properties. It is commonly used in disinfectants and sanitizers, where it can kill a broad spectrum of microorganisms including bacteria, fungi, and viruses. It is also used in water treatment to control the growth of harmful microorganisms. In addition, PHMG is used in the textile industry to create antimicrobial fabrics, and in the medical field for the sterilization of surgical instruments and other medical devices.

Safety and Toxicity

While PHMG is effective at killing microorganisms, it can also be harmful to humans and animals if not used properly. Exposure to PHMG can cause irritation to the skin, eyes, and respiratory tract. Ingestion can lead to nausea, vomiting, and in severe cases, damage to the liver and kidneys. Therefore, it is important to handle PHMG with care and to use it in a well-ventilated area.

Regulation

The use of PHMG is regulated in many countries due to its potential health risks. In the European Union, PHMG is classified as a biocide and its use is regulated by the Biocidal Products Regulation. In the United States, PHMG is regulated by the Environmental Protection Agency (EPA) under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA).

See Also

• Guanidine
• Biocide
• Disinfectant
• Sanitizer