Pranidipine

Pranidipine is a calcium channel blocker that is used primarily in the treatment of hypertension. It is a third-generation calcium channel blocker, developed in Japan and sold under the brand name Acalas.

Mechanism of Action[edit | edit source]

Pranidipine works by inhibiting the influx of calcium ions into cardiac muscle and smooth muscle cells. This inhibition leads to a decrease in muscle contraction, which in turn reduces the resistance in blood vessels and lowers blood pressure.

Pharmacokinetics[edit | edit source]

After oral administration, pranidipine is rapidly absorbed from the gastrointestinal tract. It undergoes extensive first-pass metabolism in the liver, resulting in a low bioavailability. The drug is primarily excreted in the urine.

Side Effects[edit | edit source]

Common side effects of pranidipine include headache, flushing, and dizziness. Less common side effects may include palpitations, abdominal pain, and rash.

Contraindications[edit | edit source]

Pranidipine is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with severe cardiac insufficiency.

Interactions[edit | edit source]

Pranidipine may interact with other drugs, including other calcium channel blockers, beta blockers, and ACE inhibitors. These interactions can lead to an increased risk of side effects or a decrease in the effectiveness of the drug.

References[edit | edit source]

Pranidipine Resources
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