Pregnenolone (medication)

From WikiMD's WELLNESSPEDIA

Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such, it is a prohormone. Pregnenolone is a GABA-A receptor antagonist and contributes to enhanced neurological function.

Pharmacology[edit]

Pregnenolone and its sulfate, like DHEA and its sulfate, belong to the group of neurosteroids that are found in high concentrations in certain areas of the brain, and are synthesized there. Neurosteroids affect synaptic functioning, are neuroprotective, and enhance myelinization. Pregnenolone and its sulfate ester are under investigation for their potential to improve cognitive and memory functioning.

Medical uses[edit]

Pregnenolone is used in the treatment of fatigue, Alzheimer's disease, trauma, and injuries. It is also used in the treatment of skin disorders, including psoriasis and scleroderma.

Side effects[edit]

Potential side effects of pregnenolone may include irritability, anxiety, and insomnia. Long-term effects of pregnenolone are not known.

Pharmacokinetics[edit]

Pregnenolone is lipophilic and is believed to cross the blood-brain barrier.

See also[edit]

References[edit]


External links[edit]

  • Pregnenolone.net
This article is a stub related to pharmacology. You can help WikiMD by expanding it!


Sponsored Health Resource

W8MD weight loss success

W8MD Weight Loss, Sleep & MedSpa

Looking for physician-supervised weight loss, semaglutide, tirzepatide, or GLP-1 receptor agonist options? W8MD helps eligible patients in New York City, Brooklyn, New Jersey, Connecticut, Pennsylvania, Delaware, and greater Philadelphia with medical weight loss, sleep medicine, and long-term maintenance support.

GLP-1 specials: Affordable GLP-1 injections NYC and Philadelphia starting from $29.99/week and up for semaglutide with insurance accepted for qualifying visits, and $45/week and up for tirzepatide with insurance accepted for qualifying visits. Self-pay options start from $59.99/week and up for semaglutide and $69.99/week and up for tirzepatide.

Book a W8MD appointment · View GLP-1 specials

Paid promotional message. Eligibility, pricing, insurance coverage, medication availability, and results vary. Medical evaluation required.

Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Retrieved from "https://wikimd.org/index.php?title=Pregnenolone_(medication)&oldid=6619061"