Prekallikrein

Prekallikrein is a protein that in humans is encoded by the KLKB1 gene. It is a glycoprotein present in blood plasma that is converted into kallikrein by the action of Factor XII. This conversion process is important in the blood coagulation pathway and the kinin-kallikrein system, which mediates inflammation and blood pressure.

Function

Prekallikrein is part of the contact activation system, which is a minor pathway of blood coagulation. It is converted into its active form, kallikrein, by factor XII. Kallikrein then cleaves high-molecular-weight kininogen (HMWK) to produce bradykinin, a potent vasodilator. This process is important in the regulation of blood pressure and the mediation of inflammation.

Clinical significance

Mutations in the KLKB1 gene can lead to Fletcher factor deficiency, a rare coagulation disorder. This condition is characterized by prolonged partial thromboplastin time (PTT) and can lead to a mild bleeding tendency. However, individuals with Fletcher factor deficiency do not typically have a significant bleeding risk.

See also

• Kallikrein
• Blood coagulation
• Factor XII
• Bradykinin
• Fletcher factor deficiency

External links

• KLKB1 at the NCBI Gene