Prodipine
A calcium channel blocker
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Prodipine is a calcium channel blocker of the dihydropyridine class. It is primarily used in the management of hypertension and angina pectoris.
Pharmacology[edit | edit source]
Prodipine functions by inhibiting the influx of calcium ions through L-type calcium channels in the smooth muscle cells of the vascular system. This action results in the relaxation of vascular smooth muscle, leading to vasodilation and a subsequent decrease in blood pressure.
Mechanism of Action[edit | edit source]
The primary mechanism of action of Prodipine involves the blockade of L-type calcium channels. By preventing calcium ions from entering the cells, Prodipine reduces the contractility of the heart muscle and dilates the arteries. This reduces the workload on the heart and lowers blood pressure, making it effective in treating hypertension and angina.
Pharmacokinetics[edit | edit source]
Prodipine is well absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. It is metabolized primarily by the cytochrome P450 enzyme system. The metabolites are excreted mainly in the urine.
Clinical Use[edit | edit source]
Prodipine is indicated for the treatment of hypertension and chronic stable angina. It may be used alone or in combination with other antihypertensive agents. The drug is typically administered orally.
Side Effects[edit | edit source]
Common side effects of Prodipine include headache, dizziness, flushing, and peripheral edema. These effects are generally mild and transient. Serious side effects are rare but may include hypotension and bradycardia.
Contraindications[edit | edit source]
Prodipine is contraindicated in patients with known hypersensitivity to dihydropyridines. Caution is advised in patients with severe aortic stenosis, heart failure, or hepatic impairment.
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