Progestins
Progestins[edit | edit source]
Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.
Information about Progestins[edit source]
Progestins are compounds with biological activities similar to progesterone.
List of Progestins[edit source]
Progestins developed for clinical use include desogestrel, dydrogesterone, levonorgestrel, medroxyprogesterone, megestrol, 19-nortestosterone, norethindrone, norgestrel and norgestimate, among others.
Oral contraceptives[edit | edit source]
Many of these progestins are used in combination with estrogens in oral contraceptives. In addition, some are used alone as contraceptive agents and to treat secondary amenorrhea, abnormal uterine bleeding, endometriosis, infertility and premature labor. Progestins have also been used to treat progesterone sensitive cancers (endometrial, renal, breast), and as therapy of anorexia and cachexia due to cancer chemotherapy or the acquired immunodeficiency syndrome (AIDS).
Progestins used without estrogens include (with common brand names and year of approval in the United States): medroxyprogesterone (Provera and others: 1959), megestrol (Megase: 1971) and norethindrone (Camila, Errin, Micronor, Aygestin: 1973).
Side effects of Progestins[edit source]
Common side effects of progestin therapies include nausea, headaches, anxiety, weight gain, edema and breast tenderness and engorgement.
Obstetrical and Gynecological Agents[edit source]
- Pregnancy termination agents
- Progesterone and the Progestins
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