Prostaglandin D2 receptor 1

Prostaglandin D2 receptor 1 (also known as DP1) is a protein that in humans is encoded by the PTGDR gene. It is one of two G protein-coupled receptors that bind prostaglandin D2 (PGD2), the other being Prostaglandin D2 receptor 2 (DP2).

Function

DP1 is a member of the G protein-coupled receptor family. It is a receptor for prostaglandin D2 (PGD2), a lipid mediator involved in a variety of biological processes. PGD2 binding to DP1 triggers a series of cellular signaling events that lead to biological responses such as vasodilation, bronchodilation, inhibition of platelet aggregation, and immune modulation.

Clinical significance

DP1 has been implicated in a variety of diseases, including asthma, allergic rhinitis, and cardiovascular disease. In the context of asthma, activation of DP1 by PGD2 leads to bronchodilation, suggesting a protective role. However, PGD2 can also bind to DP2, leading to pro-inflammatory effects. Therefore, the balance between DP1 and DP2 activation may be critical in asthma pathogenesis.

Pharmacology

Several drugs have been developed to target DP1. These include laropiprant, a DP1 antagonist that was developed to reduce the flushing side effect of niacin therapy, and asapiprant, a DP1 antagonist that is being investigated for the treatment of asthma.

See also

• Prostaglandin receptors
• Prostaglandin D2 receptor 2
• G protein-coupled receptor
• Prostaglandin D2

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