Prostaglandin EP2 receptor

Prostaglandin EP2 receptor (also known as EP2) is a G protein-coupled receptor that in humans is encoded by the PTGER2 gene. It is one of the four receptors identified for prostaglandin E2 (PGE2), and has been the subject of significant research due to its role in various biological functions and diseases.

Function

The Prostaglandin EP2 receptor is a member of the prostaglandin receptor family, which is a subfamily of the G protein-coupled receptor family. It is activated by the endogenous ligand PGE2. This receptor transduces the signal from PGE2 by increasing the intracellular level of cyclic AMP (cAMP) through the activation of a G protein.

Clinical significance

The Prostaglandin EP2 receptor has been implicated in a variety of diseases and conditions. It plays a significant role in the regulation of immune response, inflammation, pain perception, and fever generation. Abnormalities in the function or expression of this receptor have been associated with various pathological states, including cancer, cardiovascular disease, and neurodegenerative disease.

Research

Research into the Prostaglandin EP2 receptor has focused on its potential as a therapeutic target. Several drugs that act as selective EP2 receptor agonists or antagonists have been developed and are currently under investigation for their potential in treating various diseases.

See also

• Prostaglandin receptors
• G protein-coupled receptor
• Prostaglandin E2
• Cyclic AMP

References

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