Protein AATF

AATF (Apoptosis Antagonizing Transcription Factor) is a protein that in humans is encoded by the AATF gene. It is also known as Che-1 and DENTT. The AATF protein is a key player in various cellular processes, including cell cycle regulation, apoptosis prevention, and DNA damage response.

Function

The AATF protein is a multifunctional protein that acts as a transcription factor, regulating the expression of various genes. It is involved in the regulation of cell cycle progression and apoptosis, acting as an antagonist of cell death. AATF also plays a role in the cellular response to DNA damage, promoting cell survival in response to genotoxic stress.

Structure

The AATF protein is composed of 558 amino acids and has a molecular weight of approximately 63 kDa. It contains several functional domains, including a leucine zipper domain, which is involved in protein-protein interactions, and a nuclear localization signal, which directs the protein to the nucleus.

Clinical Significance

Mutations in the AATF gene have been associated with various diseases, including cancer. Overexpression of AATF has been observed in several types of cancer, suggesting a role in tumorigenesis. In addition, AATF has been implicated in neurodegenerative diseases, such as Alzheimer's disease, due to its role in neuronal survival.

Research

Research on AATF is ongoing, with studies focusing on its role in cell cycle regulation, apoptosis, and DNA damage response. Understanding the function of AATF and its role in disease could lead to the development of new therapeutic strategies.

See Also

• Apoptosis
• Transcription factor
• Cell cycle
• DNA damage
• Cancer
• Neurodegenerative diseases

References

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