Prothrombin complex concentrate

Prothrombin Complex Concentrate

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Prothrombin Complex Concentrate

The Prothrombin Complex Concentrate (PCC) is a medication that is primarily used in the treatment of bleeding disorders such as hemophilia. It is a concentrated source of certain blood clotting factors, including prothrombin, Factor VII, Factor IX, and Factor X.

Overview

PCC is derived from human plasma and is used to replace these clotting factors when the body's own supply is insufficient or ineffective. It is often used in emergency situations when rapid correction of a coagulopathy is required, such as in the case of severe bleeding or before an urgent surgical procedure.

Medical Uses

PCC is used in a variety of clinical scenarios, including:

• Reversal of anticoagulation in patients taking vitamin K antagonists such as warfarin
• Treatment of bleeding in patients with hemophilia B who have developed inhibitors against Factor IX
• Emergency reversal of coagulopathy in patients with major bleeding or who require urgent surgery

Side Effects

Like all medications, PCC can have side effects. These can include allergic reactions, thrombosis, and transmission of infectious agents.

Preparation and Administration

PCC is typically administered intravenously. The dose is determined based on the patient's weight and the severity of the coagulopathy.

See Also

• Blood clotting
• Hemophilia
• Coagulation factors