Protriptyline hydrochloride

Protriptyline Hydrochloride is a tricyclic antidepressant (TCA) used in the treatment of depression. It is marketed under the brand names Vivactil among others.

Pharmacology

Protriptyline hydrochloride is a type of tricyclic antidepressant (TCA), which works by inhibiting the reuptake of certain neurotransmitters in the brain, specifically norepinephrine and serotonin. This increases the concentration of these neurotransmitters in the synaptic cleft, enhancing neurotransmission and leading to an improvement in depressive symptoms.

Clinical Use

Protriptyline hydrochloride is primarily used in the treatment of depression. It may also be used off-label for conditions such as chronic pain, migraine prevention, and certain types of sleep disorders.

Side Effects

Common side effects of protriptyline hydrochloride include dry mouth, constipation, blurred vision, and dizziness. More serious side effects may include cardiac arrhythmias, seizures, and an increased risk of suicide in individuals under the age of 25.

Contraindications

Protriptyline hydrochloride is contraindicated in individuals with a history of hypersensitivity to tricyclic antidepressants, recent myocardial infarction, or any degree of heart block or other cardiac rhythm disorders.

Interactions

Protriptyline hydrochloride can interact with a number of other medications, including other antidepressants, antipsychotics, antihistamines, and anticholinergics. It is therefore important to inform healthcare providers of all medications being taken prior to starting treatment with protriptyline hydrochloride.

See Also

• Tricyclic antidepressant
• Depression
• Neurotransmitter