Quinapril hydrochloride
- the hydrochloride salt form of quinapril, a prodrug and non sulfhydryl angiotensin converting enzyme (ace) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ace, thereby blocking the conversion of angiotensin I to angiotensin ii. This abolishes the potent vasoconstrictive actions of angiotensin ii and leads to vasodilatation. Quinapril also causes a decrease in angiotensin ii induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels.
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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Quinapril hydrochloride for any updates.
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