RHBG
RHBG (Rh family, B glycoprotein), also known as RhBG or Rh (blood group) B glycoprotein, is a protein that in humans is encoded by the RHBG gene. It is a member of the Rh protein family and is structurally and functionally similar to ammonia transporters.
Function[edit | edit source]
RHBG is an ammonia transporter that can conduct ammonia and other cations across the plasma membrane. It is expressed in many tissues, including the kidney, liver, and skin, where it may be involved in pH regulation.
Structure[edit | edit source]
The RHBG protein is a member of the Rh protein family, which is part of the larger ammonia transporter family. It has 12 transmembrane domains and is structurally similar to other members of the family.
Clinical significance[edit | edit source]
Mutations in the RHBG gene have been associated with a variety of diseases, including chronic kidney disease and liver disease. Further research is needed to fully understand the role of RHBG in these conditions.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
