RNF24

RNF24 (Ring Finger Protein 24) is a protein that in humans is encoded by the RNF24 gene. This protein is a member of the RING finger protein family, characterized by a unique structural motif that binds zinc, known as the RING finger domain.

Function

RNF24 is involved in various cellular processes, including protein ubiquitination, intracellular trafficking, and signal transduction. The RING finger domain of RNF24 has been shown to possess E3 ubiquitin-protein ligase activity, which plays a crucial role in the ubiquitin-proteasome system for protein degradation.

Clinical Significance

Alterations in the RNF24 gene have been associated with several human diseases. For instance, mutations in RNF24 have been linked to neurodegenerative diseases and cancer. Further research is needed to fully understand the role of RNF24 in these diseases and its potential as a therapeutic target.

Structure

The RNF24 protein contains a RING finger domain, which is a common feature of the RING finger protein family. This domain is responsible for the protein's E3 ubiquitin-protein ligase activity. The structure of the RING finger domain is characterized by a cross-brace arrangement of eight cysteine and histidine residues that bind two zinc ions.

See Also

• RING finger domain
• Ubiquitin-proteasome system
• E3 ubiquitin-protein ligase