RNF24
RNF24 (Ring Finger Protein 24) is a protein that in humans is encoded by the RNF24 gene. This protein is a member of the RING finger protein family, characterized by a unique structural motif that binds zinc, known as the RING finger domain.
Function[edit | edit source]
RNF24 is involved in various cellular processes, including protein ubiquitination, intracellular trafficking, and signal transduction. The RING finger domain of RNF24 has been shown to possess E3 ubiquitin-protein ligase activity, which plays a crucial role in the ubiquitin-proteasome system for protein degradation.
Clinical Significance[edit | edit source]
Alterations in the RNF24 gene have been associated with several human diseases. For instance, mutations in RNF24 have been linked to neurodegenerative diseases and cancer. Further research is needed to fully understand the role of RNF24 in these diseases and its potential as a therapeutic target.
Structure[edit | edit source]
The RNF24 protein contains a RING finger domain, which is a common feature of the RING finger protein family. This domain is responsible for the protein's E3 ubiquitin-protein ligase activity. The structure of the RING finger domain is characterized by a cross-brace arrangement of eight cysteine and histidine residues that bind two zinc ions.
See Also[edit | edit source]
References[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD