RPL35

RPL35 is a gene that encodes a protein belonging to the ribosomal protein L35 family. Ribosomal proteins, such as RPL35, are components of ribosomes, which are the cellular structures responsible for protein synthesis. RPL35 is involved in the assembly and function of the 60S ribosomal subunit, playing a critical role in the translation process, where messenger RNA (mRNA) is decoded to produce polypeptide chains that eventually fold into functional proteins.

The RPL35 gene is located on chromosome 3 in humans, specifically at 3q29. The protein it encodes is highly conserved across different species, indicating its essential role in the ribosome's function. Mutations in the RPL35 gene have been studied for their potential association with various diseases, including Diamond-Blackfan anemia (DBA), a rare blood disorder characterized by failure of the bone marrow to produce enough red blood cells. However, the direct involvement of RPL35 mutations in DBA and other conditions requires further research.

In addition to its role in protein synthesis, RPL35 and other ribosomal proteins have been implicated in the regulation of cell growth and proliferation. Abnormal expression of ribosomal proteins has been observed in various cancers, suggesting that they may play a role in tumorigenesis. The study of RPL35 and its interactions within the cell is important for understanding the complex processes of cell growth, division, and the maintenance of cellular homeostasis.