RS-39604

A selective 5-HT4 receptor antagonist

RS-39604 is a chemical compound that acts as a selective antagonist for the 5-HT4 receptor. It is primarily used in scientific research to study the role of 5-HT4 receptors in various physiological processes.

Pharmacology

RS-39604 is known for its high selectivity and affinity for the 5-HT4 receptor, a subtype of the serotonin receptor family. The 5-HT4 receptor is a G protein-coupled receptor (GPCR) that is involved in the modulation of neurotransmitter release, gastrointestinal motility, and cardiac function.

Mechanism of Action

As a 5-HT4 receptor antagonist, RS-39604 binds to the receptor and inhibits its activation by endogenous serotonin (5-HT). This blockade can help elucidate the physiological and pathological roles of 5-HT4 receptors in various tissues.

Research Applications

RS-39604 is used in preclinical studies to:

• Investigate gastrointestinal motility: The 5-HT4 receptor is known to enhance gastrointestinal motility, and RS-39604 can be used to study conditions like irritable bowel syndrome (IBS) and gastroparesis.
• Study cardiac function: The receptor is also involved in cardiac function, and RS-39604 can help in understanding its role in heart rate and cardiac contractility.
• Explore central nervous system effects: Although less prominent, 5-HT4 receptors are present in the central nervous system, and RS-39604 can be used to study their role in cognition and memory.

Chemical Properties

RS-39604 has a complex chemical structure characterized by a benzofuran moiety linked to a piperidine ring. Its molecular formula is C21H23ClN2O4, and it has a molecular weight of 418.87 g/mol.

Safety and Handling

As with many research chemicals, RS-39604 should be handled with care. Appropriate safety measures, including the use of personal protective equipment (PPE), should be employed when handling this compound in a laboratory setting.

Also see

• 5-HT4 receptor
• Serotonin receptor
• G protein-coupled receptor
• Irritable bowel syndrome
• Gastroparesis

Receptor Antagonists
Receptor Type	Example Antagonists
Adrenergic receptor	Propranolol, Prazosin
Cholinergic receptor	Atropine, Scopolamine
Dopamine receptor	Haloperidol, Clozapine
Histamine receptor	Ranitidine, Diphenhydramine
Serotonin receptor	Ondansetron, Risperidone
Glutamate receptor	Memantine, Ketamine
GABA receptor	Flumazenil, Bicuculline
Opioid receptor	Naloxone, Naltrexone
Angiotensin receptor	Losartan, Valsartan