RTI-113
Chemical compound
| Drug Information | |||
|---|---|---|---|
| Image | 200 | ||
| Identifiers
ATC Code DrugBank UNII KEGG ChEBI
|
Chemical Data
| ||
RTI-113 is a phenyltropane-derived stimulant drug that acts as a potent and selective dopamine reuptake inhibitor. It is part of a class of compounds known as tropane derivatives, which are structurally related to cocaine.
Chemical Structure and Properties[edit | edit source]
RTI-113, also known by its IUPAC name (–)-2β-Carbomethoxy-3β-(4-iodophenyl)tropane, has a molecular formula of C16H20INO2. The compound features a tropane ring system with a 4-iodophenyl group attached to the 3β position and a carbomethoxy group at the 2β position.
Pharmacology[edit | edit source]
RTI-113 functions primarily as a dopamine reuptake inhibitor, which means it blocks the reabsorption of dopamine into the presynaptic neuron, leading to increased levels of dopamine in the synaptic cleft. This mechanism of action is similar to that of cocaine, although RTI-113 is more selective and potent in its effects on dopamine transporters.
Research and Applications[edit | edit source]
RTI-113 has been used extensively in scientific research to study the dopaminergic system and its role in various neurological disorders. It has been particularly useful in the investigation of addiction and substance abuse due to its high affinity for dopamine transporters.
Comparison with Other Stimulants[edit | edit source]
Compared to other stimulants such as methylphenidate and amphetamine, RTI-113 is noted for its high selectivity for dopamine transporters over other monoamine transporters. This selectivity makes it a valuable tool in research settings for isolating the effects of dopamine reuptake inhibition.
Safety and Legal Status[edit | edit source]
RTI-113 is not currently approved for medical use and is not controlled under any international drug scheduling systems. However, its structural similarity to cocaine and potent effects on the dopaminergic system suggest that it has a high potential for abuse and addiction.
See Also[edit | edit source]
References[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
