RTI-113

RTI-113 (also known as 3β-(4-Chlorophenyl)tropane-2β-carboxylic acid methyl ester) is a synthetic stimulant drug from the phenyltropane family. It is a potent and selective dopamine reuptake inhibitor with a Ki value of 0.6 nM, making it around 15x more potent than cocaine in this regard.

Pharmacology

RTI-113 is a potent and selective inhibitor of the dopamine transporter (DAT), which is responsible for the reuptake of dopamine in the synaptic cleft. By blocking this transporter, RTI-113 increases the amount of dopamine available in the brain, leading to increased stimulation of dopamine receptors and producing a stimulant effect.

Chemistry

RTI-113 is a phenyltropane based compound, and is structurally similar to cocaine. However, unlike cocaine, which is a non-selective reuptake inhibitor affecting all three monoamine transporters, RTI-113 is highly selective for the dopamine transporter.

Research

Research into RTI-113 and related compounds is ongoing, with the aim of developing new treatments for conditions such as Parkinson's disease, attention deficit hyperactivity disorder (ADHD), and drug addiction.

See also

• RTI-55
• RTI-121
• RTI-177

References

RTI-113 Resources
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