Ras p21 protein activator 2

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Ras p21 protein activator 2 (RasGAP), also known as RASA2, is a protein that in humans is encoded by the RASA2 gene. This protein is part of the GTPase-activating protein (GAP) family, which function as modulators of the Ras superfamily of proteins.

Function[edit | edit source]

Ras p21 protein activator 2 is a GTPase activating protein (GAP) for the Ras protein. It converts active Ras-GTP to the inactive form Ras-GDP. This protein is crucial in cellular signaling pathways, controlling cell growth, differentiation, and survival.

Structure[edit | edit source]

The RASA2 protein is composed of several domains, including a pleckstrin homology domain (PH domain), a C2 domain, and a GAP domain. The PH and C2 domains are involved in membrane targeting, while the GAP domain is responsible for the GTPase activating function.

Clinical significance[edit | edit source]

Mutations in the RASA2 gene have been associated with various types of cancer, including lung cancer, breast cancer, and melanoma. These mutations often result in a loss of function of the RASA2 protein, leading to uncontrolled cell growth and proliferation.

See also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD