Recombinant human parathyroid hormone

Recombinant Human Parathyroid Hormone (rhPTH) is a synthetic form of the parathyroid hormone (PTH), a protein that is naturally produced by the parathyroid glands. It is used in the treatment of various medical conditions, including osteoporosis and hypoparathyroidism.

Overview

The parathyroid hormone is a critical regulator of calcium homeostasis in the human body. It acts on the bones, kidneys, and intestine to increase the level of calcium in the blood. Recombinant human parathyroid hormone is a synthetic version of this hormone, produced through recombinant DNA technology.

Medical Uses

Recombinant human parathyroid hormone is used in the treatment of osteoporosis, a condition characterized by weak and brittle bones. It works by stimulating the formation of new bone, thereby increasing bone density and reducing the risk of fractures.

In addition, rhPTH is used in the treatment of hypoparathyroidism, a condition in which the body produces insufficient amounts of the parathyroid hormone. In this case, rhPTH serves as a replacement for the natural hormone, helping to regulate calcium levels in the body.

Production

Recombinant human parathyroid hormone is produced using recombinant DNA technology. This involves inserting a gene that codes for the parathyroid hormone into a suitable host organism, such as a bacterium or yeast. The host organism then produces the hormone, which can be harvested and purified for medical use.

Side Effects

Like all medications, recombinant human parathyroid hormone can cause side effects. These may include nausea, headache, and dizziness. In rare cases, it can cause high levels of calcium in the blood, a condition known as hypercalcemia.

See Also

• Parathyroid hormone
• Osteoporosis
• Hypoparathyroidism
• Recombinant DNA