Reflux suppressant

A reflux suppressant is a category of medications designed to counteract oesophageal reflux, a common medical condition where stomach contents flow back into the oesophagus, often resulting in heartburn, regurgitation, and discomfort. These drugs employ various mechanisms to provide relief and protection from the harmful effects of reflux.

Mechanism of Action

Upon ingestion, many reflux suppressants prompt the formation of an 'alginate raft', which originates from alginic acid. This raft floats on top of the stomach contents, created by the release of carbon dioxide from the drug. This floating barrier acts as a mechanical shield, preventing further reflux of stomach contents into the oesophagus.

In addition to this primary mechanism, certain formulations of reflux suppressants include antacids. These substances can neutralize stomach acid, providing further protection to the oesophagus and reducing symptoms.

Moreover, some agents, notably motility stimulants and antidopaminergics, can inadvertently reduce reflux by enhancing gastrointestinal motility or by exerting effects on the dopaminergic system.

Medications in This Class

• Alginic acid - Often found in combination with antacids.
• Motility stimulants - These drugs increase the movement of the gastrointestinal tract, potentially reducing reflux.
• Antidopaminergics - While not primary reflux suppressants, their effects can reduce reflux.

Clinical Use

Reflux suppressants are primarily prescribed to patients suffering from conditions such as gastroesophageal reflux disease (GERD) or those who experience frequent heartburn. These medications can offer relief from symptoms and prevent potential complications like oesophagitis or Barrett's oesophagus.

See Also

• Antacid
• Gastroesophageal reflux disease
• Oesophagus

References

Reflux suppressant Resources
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