Relcovaptan

Relcovaptan is a vasopressin antagonist used in the treatment of hyponatremia (low blood sodium levels) associated with syndrome of inappropriate antidiuretic hormone (SIADH). It is also being studied for potential use in the treatment of congestive heart failure.

Mechanism of Action

Relcovaptan works by blocking the action of vasopressin, a hormone that regulates the body's water balance. This allows the kidneys to excrete excess water, thereby increasing blood sodium levels.

Uses

Relcovaptan is primarily used to treat hyponatremia associated with SIADH. It may also be used off-label for other conditions characterized by low blood sodium levels, such as cirrhosis and nephrotic syndrome.

Side Effects

Common side effects of relcovaptan include dry mouth, thirst, and increased urination. Less common but more serious side effects can include rapid correction of hyponatremia, which can lead to osmotic demyelination syndrome, a serious and potentially fatal brain condition.

Research

Research is ongoing into the potential use of relcovaptan in the treatment of congestive heart failure. Early studies suggest that it may help to reduce fluid overload and improve symptoms in these patients.

See Also

• Vasopressin antagonist
• Hyponatremia
• Syndrome of inappropriate antidiuretic hormone
• Congestive heart failure

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