Relcovaptan

Relcovaptan is a vasopressin antagonist used in the treatment of hyponatremia (low blood sodium levels) associated with syndrome of inappropriate antidiuretic hormone (SIADH). It is also being studied for potential use in the treatment of congestive heart failure.

Mechanism of Action[edit | edit source]

Relcovaptan works by blocking the action of vasopressin, a hormone that regulates the body's water balance. This allows the kidneys to excrete excess water, thereby increasing blood sodium levels.

Uses[edit | edit source]

Relcovaptan is primarily used to treat hyponatremia associated with SIADH. It may also be used off-label for other conditions characterized by low blood sodium levels, such as cirrhosis and nephrotic syndrome.

Side Effects[edit | edit source]

Common side effects of relcovaptan include dry mouth, thirst, and increased urination. Less common but more serious side effects can include rapid correction of hyponatremia, which can lead to osmotic demyelination syndrome, a serious and potentially fatal brain condition.

Research[edit | edit source]

Research is ongoing into the potential use of relcovaptan in the treatment of congestive heart failure. Early studies suggest that it may help to reduce fluid overload and improve symptoms in these patients.