Renzapride
Renzapride is a gastroprokinetic agent and antiemetic which was developed by Alizyme plc but is no longer being actively pursued. It acts as a 5-HT4 receptor agonist and 5-HT3 receptor antagonist. The compound was under investigation for the treatment of gastrointestinal disorders such as gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS).
Pharmacology[edit | edit source]
Renzapride is a serotonin receptor modulator, with a high affinity for the 5-HT4 and 5-HT3 receptors. It acts as an agonist at the 5-HT4 receptor, which stimulates the peristalsis that moves content through the gastrointestinal tract. It also acts as an antagonist at the 5-HT3 receptor, which reduces the sensation of nausea and vomiting.
Clinical Trials[edit | edit source]
Renzapride was in Phase III clinical trials for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) in women. However, the trials did not meet their primary efficacy endpoint and development was discontinued.
Side Effects[edit | edit source]
The most common side effects reported in clinical trials were headache, nausea, and diarrhea. Serious side effects were rare, but included cardiac arrhythmia and hypersensitivity reactions.
History[edit | edit source]
Renzapride was developed by the British biopharmaceutical company Alizyme plc. The compound entered clinical trials in the early 2000s, but development was halted after Phase III trials failed to meet their primary endpoint.
See Also[edit | edit source]
- 5-HT4 receptor
- 5-HT3 receptor
- Gastroprokinetic agent
- Antiemetic
- Gastroesophageal reflux disease
- Irritable bowel syndrome
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
 | This gastroenterology article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
