Rev-ErbA alpha
Rev-ErbA alpha (also known as NR1D1 for Nuclear Receptor Subfamily 1, Group D, Member 1) is a nuclear receptor that in humans is encoded by the NR1D1 gene. It is a member of the nuclear receptor family of intracellular transcription factors and plays a critical role in the regulation of circadian rhythms, metabolism, and immune function.
Function[edit | edit source]
Rev-ErbA alpha functions as a transcriptional repressor and is involved in the regulation of various physiological processes. It is a key component of the circadian clock, where it negatively regulates the expression of BMAL1 (Brain and Muscle ARNT-Like 1), a core clock gene, thereby contributing to the maintenance of circadian rhythm. In addition to its role in the circadian clock, Rev-ErbA alpha influences lipid and glucose metabolism, making it a potential target for the treatment of metabolic disorders such as obesity and diabetes.
Structure[edit | edit source]
The Rev-ErbA alpha protein contains a DNA-binding domain (DBD) and a ligand-binding domain (LBD). The DBD allows the protein to bind to specific DNA sequences, known as Rev-Drb response elements (RevREs), to regulate gene expression. The LBD can bind to heme, which acts as a ligand, modulating the receptor's activity in response to intracellular heme levels.
Clinical Significance[edit | edit source]
Alterations in the expression or function of Rev-ErbA alpha have been associated with various health conditions, including metabolic syndrome, cardiovascular diseases, and certain cancers. Its role in the circadian regulation makes it a potential target for the treatment of sleep disorders and the adverse health effects associated with shift work and jet lag.
Research[edit | edit source]
Research on Rev-ErbA alpha has focused on its potential as a therapeutic target for metabolic and circadian rhythm disorders. Synthetic ligands that selectively target Rev-ErbA alpha have been developed, showing promise in the regulation of metabolism and the enhancement of circadian rhythm synchronization.
See Also[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD