Rhodococcus equi

Rhodococcus equi is a gram-positive, intracellular bacterium that is a significant pathogen primarily affecting foals, causing a disease known as rhodococcosis. This bacterium is also capable of infecting humans, particularly those with compromised immune systems, leading to conditions such as pneumonia. Rhodococcus equi is commonly found in soil and manure environments, making equine living quarters a potential hotspot for infection.

Characteristics

Rhodococcus equi is characterized by its coccobacillary shape and its ability to form rough colonies on agar plates. It is a facultative anaerobe that can survive and multiply in both aerobic and anaerobic conditions. The bacterium is known for its distinctive pink to salmon-colored colonies due to the presence of carotenoid pigments, which are thought to play a role in its pathogenicity and resistance to oxidative stress.

Pathogenesis

The pathogenicity of Rhodococcus equi is primarily attributed to its ability to survive and replicate within macrophages, the immune cells responsible for engulfing and destroying pathogens. The bacterium possesses a virulence plasmid that encodes for proteins essential for its survival within the host's cells. In foals, the infection typically manifests as pyogranulomatous pneumonia, but it can also affect the intestinal tract and other organs.

Transmission

Transmission of Rhodococcus equi occurs mainly through the inhalation of dust contaminated with spores from the feces of infected animals. The high bacterial load in the environment of equine breeding and rearing facilities contributes to the spread of the disease. Direct contact with infected animals or fomites is less commonly involved in the transmission.

Clinical Signs and Diagnosis

In foals, the clinical signs of rhodococcosis include coughing, fever, lethargy, and difficulty breathing. The disease can progress rapidly, leading to severe respiratory distress and, if untreated, death. Diagnosis is based on clinical signs, radiographic findings, and the isolation of the bacterium from clinical samples such as tracheal aspirates or lung biopsies.

Treatment and Prevention

Treatment of Rhodococcus equi infections involves a combination of antibiotics, with macrolides and rifampin being the most commonly used due to their ability to penetrate macrophages and kill the intracellular bacteria. Prevention strategies focus on reducing environmental contamination through proper manure management and maintaining good air quality in barns and stables. Vaccines are under development but are not yet widely available.

Human Infections

Although less common, Rhodococcus equi can infect immunocompromised humans, such as those with HIV/AIDS or undergoing immunosuppressive therapy. In humans, the bacterium can cause pulmonary infections similar to those seen in foals, as well as extrapulmonary infections including bacteremia and abdominal abscesses.

See Also

• Zoonosis
• Pneumonia
• Immunocompromised host
• Macrolide antibiotics

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian