Ribose 1-dehydrogenase (NADP+)

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Ribose 1-dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction of D-ribose to D-ribulose. This reaction involves the transfer of a hydride ion from the substrate to the coenzyme nicotinamide adenine dinucleotide phosphate (NADP+). The systematic name of this enzyme class is D-ribose:NADP+ 1-oxidoreductase. Other names in common use include D-ribose dehydrogenase, and D-ribose (nicotinamide adenine dinucleotide phosphate) dehydrogenase.

Function[edit | edit source]

Ribose 1-dehydrogenase (NADP+) is part of the oxidoreductase family of enzymes, which play a crucial role in the metabolism of carbohydrates. Specifically, it is involved in the pentose phosphate pathway, a metabolic pathway parallel to glycolysis that generates NADPH and pentoses.

Structure[edit | edit source]

The enzyme is a protein that consists of a single polypeptide chain. It contains a Rossmann fold, a common protein motif found in proteins that bind nucleotides, such as NADP+.

Clinical significance[edit | edit source]

Alterations in the activity of Ribose 1-dehydrogenase (NADP+) can have significant effects on the pentose phosphate pathway, potentially leading to metabolic disorders. Further research is needed to fully understand the implications of these alterations in human health and disease.

See also[edit | edit source]

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