Rigosertib
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Rigosertib (ON-01910 sodium salt, with Estybon as trade name) is a synthetic benzyl styryl sulfone in development by Onconova Therapeutics.[1] Riosertib is in phase III clinical trials for the treatment of chronic myelomonocytic leukemia.[2]
Its geometrical isomer (Z)-ON 01910·Na has less cytotoxicity on cancer cells.
Mechanism[edit]
Rigosertib is a microtubule-destabilizing agent.[3]
References[edit]
- ↑ Onconova Therapeutics. Accessed 2019-04-26.
- ↑ https://clinicaltrials.gov/ct2/show/NCT01928537
- ↑ "Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent".Molecular Cell.2017;68(1)
- 210–223.e6.doi:10.1016/j.molcel.2017.09.012.PMID:28985505.PMC:5640507.Full text.
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