Rigosertib

From WikiMD's Wellness Encyclopedia


Rigosertib (ON-01910 sodium salt, with Estybon as trade name) is a synthetic benzyl styryl sulfone in development by Onconova Therapeutics.[1] Riosertib is in phase III clinical trials for the treatment of chronic myelomonocytic leukemia.[2]

Its geometrical isomer (Z)-ON 01910·Na has less cytotoxicity on cancer cells.

Mechanism[edit | edit source]

Rigosertib is a microtubule-destabilizing agent.[3]

References[edit | edit source]

  1. ↑ "Onconova Therapeutics". Retrieved 2019-04-26.
  2. ↑ https://clinicaltrials.gov/ct2/show/NCT01928537
  3. ↑


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Contributors: Prab R. Tumpati, MD