Robert Bruce Merrifield

R._B._Merrifield

Robert Bruce Merrifield (July 15, 1921 – May 14, 2006) was an American biochemist who won the Nobel Prize in Chemistry in 1984 for the invention of the solid-phase peptide synthesis method. This groundbreaking technique revolutionized the field of biochemistry and pharmacology by allowing for the rapid and efficient synthesis of peptides and proteins.

Early Life and Education

Merrifield was born in Fort Worth, Texas. He attended Pasadena Junior College and later transferred to the University of California, Los Angeles (UCLA), where he earned his B.S. in chemistry in 1943. He continued his studies at UCLA, obtaining a Ph.D. in biochemistry in 1949.

Career and Research

After completing his Ph.D., Merrifield joined the Rockefeller Institute for Medical Research (now Rockefeller University) in New York City. It was here that he developed the solid-phase peptide synthesis method, which he first published in 1963. This method involves anchoring the first amino acid of a peptide chain to an insoluble solid support, allowing for the sequential addition of amino acids to build the desired peptide.

The solid-phase peptide synthesis technique significantly improved the efficiency and speed of peptide synthesis, which had previously been a laborious and time-consuming process. This innovation had a profound impact on the study of proteins and the development of new pharmaceuticals.

Awards and Honors

In recognition of his contributions to science, Merrifield received numerous awards and honors, including the Nobel Prize in Chemistry in 1984. He was also a member of the National Academy of Sciences and received the Gairdner Foundation International Award.

Personal Life

Merrifield was married to Elizabeth Furlong, and they had six children. He passed away on May 14, 2006, in Cresskill, New Jersey.

Legacy

Merrifield's invention of solid-phase peptide synthesis remains a cornerstone of modern biochemistry and pharmacology. His work has enabled countless advancements in the understanding of protein structure and function, as well as the development of new therapeutic agents.

Related Pages

• Nobel Prize in Chemistry
• Solid-phase peptide synthesis
• Biochemistry
• Pharmacology
• Rockefeller University