S1PR4

S1PR4 or Sphingosine-1-phosphate receptor 4 is a protein that in humans is encoded by the S1PR4 gene. It is a member of the sphingosine-1-phosphate receptor family, which is a group of G protein-coupled receptors that are cell surface receptors.

Function

S1PR4 is a receptor for the bioactive lipid sphingosine 1-phosphate (S1P). S1P is a circulating lipid that binds to the S1PR4 receptor, leading to the activation of intracellular signaling pathways. This receptor is known to regulate the immune system, particularly in the context of inflammation and autoimmune diseases.

Clinical significance

Alterations in the function of S1PR4 have been implicated in a variety of diseases, including cancer, autoimmune diseases, and inflammatory diseases. For example, in certain types of cancer, the overexpression of S1PR4 has been associated with increased tumor growth and metastasis. In autoimmune diseases, S1PR4 has been found to play a role in the migration and function of immune cells.

Research

Research into the role of S1PR4 in disease is ongoing, with a particular focus on its potential as a therapeutic target. For example, drugs that target S1PR4 are being developed for the treatment of autoimmune diseases and cancer.

File:S1PR4.png

S1PR4 protein structure

See also

• Sphingosine-1-phosphate receptor
• G protein-coupled receptor
• Lipid signaling