S1PR4
S1PR4[edit | edit source]
S1PR4 (Sphingosine-1-phosphate receptor 4) is a G protein-coupled receptor that binds the lipid signaling molecule sphingosine-1-phosphate (S1P). This receptor is part of the sphingosine-1-phosphate receptor family, which plays a crucial role in the regulation of various physiological processes, including immune system function and cardiovascular development.
Function[edit | edit source]
S1PR4 is primarily expressed in lymphoid tissue and is involved in the modulation of immune cell trafficking and function. It is known to influence the behavior of T cells, B cells, and natural killer cells. The receptor's activity is mediated by its interaction with intracellular G proteins, which transduce signals to downstream effectors, influencing cell migration, proliferation, and survival.
Clinical Significance[edit | edit source]
Alterations in S1PR4 signaling have been implicated in various disease states, including autoimmune disorders and cancer. The receptor is a potential target for therapeutic intervention in conditions where immune cell regulation is disrupted.
Research[edit | edit source]
Recent studies have focused on the role of S1PR4 in inflammatory diseases and its potential as a biomarker for disease progression. The development of selective S1PR4 agonists and antagonists is an area of active research, aiming to modulate immune responses in a controlled manner.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
