SB-216641

From WikiMD's Wellnesspedia

SB-216641 is a compound that is used in scientific research. It acts as a selective antagonist for the 5-HT1B receptor, which is a subtype of the 5-HT receptor that binds to the neurotransmitter serotonin. SB-216641 is used to study the role of 5-HT1B receptors in various processes including anxiety, depression, and drug addiction.

Pharmacology[edit | edit source]

SB-216641 is a potent and selective antagonist for the 5-HT1B receptor. It has a high affinity for this receptor subtype, with a Ki value of 1.4 nM. This makes it a useful tool for studying the role of 5-HT1B receptors in the brain and other tissues.

Uses in Research[edit | edit source]

SB-216641 has been used in a variety of research studies to investigate the role of 5-HT1B receptors in different physiological and pathological processes. These include studies on anxiety, depression, drug addiction, and migraine.

Anxiety and Depression[edit | edit source]

Research has shown that 5-HT1B receptors play a role in the regulation of mood and anxiety. SB-216641 has been used in animal models to investigate this role further. For example, it has been shown that administration of SB-216641 can increase anxiety-like behavior in rats, suggesting that 5-HT1B receptors may have an anxiolytic effect.

Drug Addiction[edit | edit source]

SB-216641 has also been used to study the role of 5-HT1B receptors in drug addiction. Studies have shown that these receptors may be involved in the reinforcing effects of drugs of abuse, such as cocaine and amphetamines. SB-216641 has been used to investigate this role further.

Migraine[edit | edit source]

5-HT1B receptors are thought to be involved in the pathophysiology of migraine. SB-216641 has been used in research to investigate this role further. For example, it has been shown that administration of SB-216641 can inhibit the vasodilation that is associated with migraine, suggesting that 5-HT1B receptors may be a potential target for the treatment of this condition.

See Also[edit | edit source]


SB-216641 Resources

Find a healthcare provider anywhere in the world quickly and easily!

Wiki.png

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD


Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.


Contributors: Prab R. Tumpati, MD