SB-399885

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SB-399885 is a drug that is used in scientific research. It is a potent and selective 5-HT6 receptor antagonist. SB-399885 is used primarily in the study of the serotonin system and its role in neurological disorders and neuropsychiatric disorders.

Chemistry[edit | edit source]

SB-399885 is a small molecule with a molecular weight of 448.9 g/mol. It is a derivative of pyridine and pyrazole, with additional fluorine and chlorine atoms. The chemical formula of SB-399885 is C20H16ClF3N4O2.

Pharmacology[edit | edit source]

SB-399885 acts by binding to the 5-HT6 receptor and blocking its activation by serotonin. This receptor subtype is found primarily in the brain, particularly in regions associated with learning and memory such as the cortex and hippocampus. By blocking the action of serotonin at this receptor, SB-399885 can modulate the activity of neural circuits and influence behavior.

Research Applications[edit | edit source]

SB-399885 has been used in a variety of research contexts. It has been used to investigate the role of the 5-HT6 receptor in cognition, mood, and appetite. It has also been used in studies of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, as well as in research on schizophrenia and depression.

Safety and Toxicity[edit | edit source]

As a research chemical, SB-399885 is not intended for human consumption. Its safety and toxicity in humans have not been thoroughly studied. In animal studies, it has been shown to have a good safety profile at doses used for research purposes.

See Also[edit | edit source]

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