SFRS7

SFRS7 or Serine/Arginine-Rich Splicing Factor 7 is a protein that in humans is encoded by the SFRS7 gene. It is a member of the serine/arginine (SR) rich family of pre-mRNA splicing factors, which constitute part of the spliceosome.

Function

SFRS7 is involved in mRNA processing, specifically in the splicing of pre-mRNA. It is a component of the spliceosome, a complex of enzymes that removes introns from a transcribed pre-mRNA segment. This editing process is a crucial step in the generation of mature mRNA, which can then be translated into a functional protein molecule.

Structure

The SFRS7 protein contains two RNA recognition motifs (RRMs) and one RS domain, which is rich in serine and arginine residues. The RS domain is required for both protein-protein interactions and the assembly of the spliceosome.

Clinical Significance

Mutations in the SFRS7 gene have been associated with various diseases, including cancer. The aberrant splicing of pre-mRNA is a common feature in cancer and is thought to contribute to its progression.

See Also

• Spliceosome
• mRNA Splicing
• Serine/Arginine (SR) Rich Family

References

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