SIN3A

SIN3A is a protein that in humans is encoded by the SIN3A gene. This protein is a component of the histone deacetylase complex, which is involved in the regulation of gene expression by modifying chromatin structure.

Function

SIN3A is a core component of the histone deacetylase complex, which plays a critical role in the regulation of transcription by altering the acetylation status of histones. This modification affects the accessibility of DNA to transcription factors and other proteins, thereby influencing gene expression.

Interactions

SIN3A interacts with a variety of proteins, including:

• HDAC1 and HDAC2 - Histone deacetylases that are part of the same complex.
• SAP30 - A protein that helps recruit SIN3A to specific genomic locations.
• MECP2 - A protein involved in gene silencing and associated with Rett syndrome.

Clinical significance

Mutations or dysregulation of SIN3A have been implicated in various cancers and neurological disorders. Its role in epigenetic regulation makes it a potential target for therapeutic interventions.

See also

• Histone deacetylase
• Chromatin remodeling
• Gene regulation

External links

• Template:GeneReviews
• Online Mendelian Inheritance in Man (OMIM) 607776