SIRPB1

SIRPB1 or Signal-regulatory protein beta 1 is a protein that in humans is encoded by the SIRPB1 gene. It is a member of the signal-regulatory protein (SIRP) family, and also known as SIRP-beta-1.

Function

SIRPB1 is an immunoglobulin-like cell surface receptor for CD47. It is involved in the regulation of immune cell responses to neoplastic cells and plays a role in immune surveillance, neutrophil activation, and macrophage adhesion.

Structure

The SIRPB1 protein is a transmembrane protein that is composed of three immunoglobulin superfamily domains, a single transmembrane region, and a cytoplasmic tail. The extracellular region of SIRPB1 interacts with CD47, while the cytoplasmic region is involved in transmitting intracellular signals.

Clinical significance

Alterations in the SIRPB1 gene have been associated with susceptibility to infectious diseases, autoimmune diseases, and cancer. In particular, SIRPB1 has been implicated in the immune evasion of cancer cells, and is being investigated as a potential target for cancer immunotherapy.

See also

• CD47
• Signal-regulatory protein
• Immunoglobulin superfamily
• Cancer immunotherapy

External links

• SIRPB1 at the National Center for Biotechnology Information

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