SLC22A11

SLC22A11 is a gene that in humans encodes the organic anion transporter 4 (OAT4). This protein is a transmembrane protein primarily found in the kidneys and placenta, where it plays a crucial role in the elimination and reabsorption of various endogenous and exogenous substances.

Function

The protein encoded by the SLC22A11 gene is involved in the transport of organic anions. It is expressed in the kidney and placenta, where it functions to eliminate waste products and drugs from the body and to regulate the levels of various substances in the body. The protein is part of the solute carrier family 22 (organic anion transporter), member 11, and is a multi-pass membrane protein.

Clinical significance

Mutations in the SLC22A11 gene have been associated with various medical conditions. For example, they have been linked to hypertension, gout, and certain types of cancer. Further research is needed to fully understand the role of this gene in disease development and progression.

Research

Research into the SLC22A11 gene and its encoded protein is ongoing. Studies are focusing on understanding the exact mechanisms of action of the protein, as well as its role in disease. This research could potentially lead to the development of new treatments for diseases associated with mutations in this gene.

See also

• Solute carrier family
• Organic anion transporter
• Kidney
• Placenta