SLC2A6

SLC2A6 also known as Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene. It is a member of the solute carrier family which primarily functions to transport various molecules across the cell membranes.

Function

SLC2A6 is a member of the glucose transporter type class of membrane transport proteins. This protein helps facilitate the transport of fructose from the lumen of the intestine into the enterocytes. It is also involved in the transport of fructose in the kidney.

Clinical Significance

Mutations in the SLC2A6 gene have been associated with Fructose intolerance, a metabolic disorder characterized by the inability to digest fructose. This can lead to a range of symptoms including abdominal pain, diarrhea, and malabsorption.

Structure

The SLC2A6 protein is composed of 12 transmembrane domains with both the N and C terminus located intracellularly. The protein also contains a large intracellular loop between the 6th and 7th transmembrane domains.

See Also

• Solute carrier family
• Glucose transporter
• Fructose intolerance