SLITRK1

SLITRK1 is a protein that in humans is encoded by the SLITRK1 gene. It is a member of the SLITRK family, which are integral membrane proteins that have been implicated in neuronal development. Mutations in this gene have been linked to Tourette syndrome.

Function

SLITRK1 is a member of the SLITRK protein family. These proteins are integral membrane proteins that are involved in the development of neurons. They are characterized by two leucine-rich repeat (LRR) domains and a carboxy-terminal domain that shares homology with bacterial and viral proteins.

SLITRK1 is expressed in the brain, particularly in the cerebral cortex, hippocampus, and thalamus. It has been shown to play a role in neurite outgrowth and may be involved in the development of the nervous system.

Clinical significance

Mutations in the SLITRK1 gene have been associated with Tourette syndrome, a neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics. The exact mechanism by which these mutations lead to Tourette syndrome is not yet fully understood.

See also

• SLITRK2
• SLITRK3
• SLITRK4
• SLITRK5
• SLITRK6

External links

• NCBI Gene
• UniProt

SLITRK1 Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski