SNX1

SNX1 or Sorting Nexin 1 is a protein that in humans is encoded by the SNX1 gene. It is a member of the Sorting Nexin family, a diverse group of proteins which are involved in several cellular processes, particularly in intracellular protein trafficking.

Function

SNX1 is involved in the endocytosis process, which is the internalization of plasma membrane proteins and lipids. It plays a crucial role in the sorting and degradation of receptors, and in the formation of endosomes. SNX1 is also involved in the regulation of trans-Golgi network (TGN) sorting.

Structure

The SNX1 protein contains a PX (Phox homology) domain, a unique structural module that has a high affinity for phosphoinositides. This domain is essential for the protein's function in intracellular trafficking.

Clinical Significance

Alterations in the SNX1 gene have been associated with several diseases. For example, mutations in SNX1 have been linked to Alzheimer's disease, as the protein is involved in the trafficking of the amyloid precursor protein, which is implicated in the disease's pathology.

See Also

• Sorting Nexin
• Protein Trafficking
• Endocytosis
• Trans-Golgi Network

References

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian